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目的了解宫颈细胞学和高危型人乳头瘤病毒(high risk-human papillomavirus,HR-HPV)联合检查的必要性。方法对2013年12月至2014年12月在南京医科大学附属南京妇幼保健院门诊进行妇科检查,细胞学阴性/HR-HPV阳性的235例患者进行阴道镜检查和宫颈活组织病理检查,对其结果进行分析。结果 235例患者中,85例感染HPV 16/18型,宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)≥Ⅱ级19例(22.35%);150例感染其余各型,≥CINⅡ的16例(10.67%),差异有统计学意义(P﹤0.05)。结论细胞学和HR-HPV联合检查提高了CIN和宫颈癌的检出率,HR-HPV16/18的检出更有助于识别那些处于最高风险患CIN的女性,更有利于对宫颈癌的早期发现和诊治。
Objective To understand the necessity of cervical cytology and high risk human papillomavirus (HR-HPV) combined examination. Methods From December 2013 to December 2014, gynecological examinations were performed in outpatient department of Nanjing Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University. The cytology negative / HR-HPV positive 235 patients underwent colposcopy and cervical biopsy, Results were analyzed. Results Of the 235 patients, 85 cases were infected with HPV type 16/18, 19 cases (22.35%) with grade Ⅱ cervical intraepithelial neoplasia (CIN), and 16 cases 10.67%), the difference was statistically significant (P <0.05). Conclusions Cytology and HR-HPV combined test can improve the detection rate of CIN and cervical cancer. The detection of HR-HPV16 / 18 is more helpful to identify those women who are at the highest risk of CIN and more conducive to the early stage of cervical cancer Discover and diagnose.