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过氧化物酶体增殖物激活受体(PPAR)γ属于核激素受体超家族中的一员,它在调控细胞的生长、分化及凋亡等方面起重要作用。配体激活的PPARγ可抑制肿瘤细胞的生长和转移,促进肿瘤细胞分化和凋亡。此文就PPARγ与胃肠肿瘤的研究进展作一综述。
Peroxisome proliferator-activated receptor (PPAR) γ belongs to the nuclear hormone receptor superfamily and plays an important role in the regulation of cell growth, differentiation and apoptosis. Ligand-activated PPARγ can inhibit the growth and metastasis of tumor cells and promote tumor cell differentiation and apoptosis. This article reviews the research progress of PPARγ and gastrointestinal tumors.