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金黄色葡萄球菌(Staphyloccocus aureus)是人类的一种重要病原菌,它广泛存在于自然界中,食品受其污染的机会很多,极易引起中毒事件,危害人们的健康。据美国疾病控制中心报告,金黄色葡萄球菌引起的感染占第二位,仅次于大肠杆菌。因此,有效地检测出金黄色葡萄球菌并将其杀灭,对人们的健康有重大意义。在2012年的iGEM比赛中,哈尔滨工业大学参赛队伍HIT-harbin队利用合成生物学手段将原本属于金黄色葡萄球菌的agr群体感应系统移植到大肠杆菌中,用来检测环境中的金黄色葡萄球菌,并利用溶葡球菌酶来杀灭环境中的金黄色葡萄球菌。为了实验的顺利进行,先对这个新设计的系统进行了计算机模拟,得一些足以指导实验进行的数据。
Staphyloccocus aureus is an important pathogen of human beings. It exists in nature extensively. There are many chances that food will be contaminated by it. It will cause poisoning easily and endanger people’s health. According to the U.S. Centers for Disease Control and Prevention, the number of infections caused by Staphylococcus aureus is second only to that of E. coli. Therefore, the effective detection of Staphylococcus aureus and its killing, is of great significance to people’s health. In 2012 iGEM competition, Harbin Institute of Technology team HIT-harbin team using synthetic biology means will originally belong to the Staphylococcus aureus agr swarm transplanted into E. coli, used to detect the environment of Staphylococcus aureus , And the use of lysostaphin to kill the environment of Staphylococcus aureus. In order to experiment smoothly, first of all the new design of the computer simulation system, got some enough to guide the experimental data.