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自1963年发现萘啶酸(表一)以来,人们已经合成和评价了其大量的类似物,它们作为抗革兰氏阴性菌药物,有些已进入国际医药市场。1977年前已有一篇较全面的综述,总结了这类化合物的合成方法、微生物学性质和结构与活性的关系。
Since Nalidixic acid (Table 1) was discovered in 1963, a large number of analogs have been synthesized and evaluated as anti-Gram-negative bacteria and some have entered the international pharmaceutical market. Before 1977 there was a more comprehensive review summarizing the synthesis of these compounds, the nature of microbiology and the relationship between structure and activity.