目的　研究重组戊型肝炎疫苗的免疫原性。方法　通过对小鼠、新西兰兔的多点皮内注射及肌肉注射 ,然后测定其抗体效价 ,研究重组戊型肝炎疫苗的性能。结果　小鼠在免疫 7d后开始产生抗体 ,两周抗体阳性率为80 % ,四周抗体阳性率达 10 0 %。新西兰兔从第二周后开始产生抗体 ,第三周达到高峰 ,抗血清在 1∶6 4 0 0稀释度的阳性率达 4 0 %。结论　重组戊型肝炎疫苗免疫动物具有良好的免疫原性 ,为进一步研究开发戊肝疫苗对人体的免疫提供了基础 Objective To study the immunogenicity of recombinant hepatitis E vaccine. Methods The mice and New Zealand rabbits were injected intradermally intramuscularly and intramuscularly, and their antibody titers were measured to study the performance of the recombinant hepatitis E vaccine. Results The mice started to produce antibodies after 7 days of immunization. The positive rate of antibody in two weeks was 80% and the positive rate of antibodies in four weeks was 100%. New Zealand rabbits began to produce antibodies from the second week after the third week of peak, antisera at 1: 640 dilution of the positive rate of 40%. Conclusion Recombinant HEV vaccines have good immunogenicity for immunization and provide the basis for further research on the development of HEV vaccines on human immunity