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中药饮片规格与质量均一性是影响临床疗效的重要因素。针对现有中药饮片规格混乱多样与质量均一性差,与临床疗效关系不明确的不足,首次提出了面向临床的、依托趁鲜加工技术的中药精标饮片(precision decoction pieces,PDP)研究思路与方法;并以有毒中药附子为例,从规格设计、炮制工艺、饮片煎煮、质量均一性、毒效成分转移规律等角度对精标饮片进行系统评价。结果显示,采用趁鲜切制技术加工5 mm规格的附子定尺颗粒简单易行,效率高、产量大;能显著降低成分的损失,提高药效成分的含量;实现了饮片规格与质量的均一化;同时,能最大限度地促进药效成分的煎出,提高药物利用率。该结果揭示了精标饮片品质的优越性,有助于提高临床疗效,为推动中药饮片形制规格的标准化与加工方法的现代化提供思路、方法与范例。
Chinese medicine Pieces uniformity of quality and specification is an important factor affecting the clinical efficacy. In view of the chaotic variety and poor quality uniformity of the existing Chinese medicine decoction pieces and the lack of clear relation with the clinical curative effect, a clinical-oriented research idea and method of precision decoction pieces (PDP) based on the fresh processing technology is proposed for the first time. ; And taking the poisonous traditional Chinese medicine aconite as an example, we systematically evaluate the precision standard pieces from the point of view of the specification design, the processing technology, the decoction of the decoction pieces, the homogeneity of the quality and the rule of the transfer of toxic ingredients. The results show that the use of fresh cut technology processing 5 mm size of aconite ruler particles simple and easy, high efficiency, large output; can significantly reduce the loss of ingredients and improve the content of the drug ingredients; to achieve the uniformity of the size and quality of the pieces At the same time, to maximize the promotion of the efficacy of ingredients fried, improve drug utilization. The results revealed the superiority of the quality of the refined curatives and helped to improve the clinical curative effect. The results provided the ideas, methods and examples for the standardization and the modernization of the processing methods.