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作者采用双抗体放射免疫测定法对34例急性脑血管病(CVD)、30例脱髓鞘疾病(DMD)及26例其他神经系统疾病(OND)患者的血清和脑脊液的髓鞘碱性蛋白(MBP)进行了测定。结果表明,急性CVD患者血清MBP平均含量及阳性率明显高于DMD与0ND的患者,差别有显著性(P<0.06).在脑脊液(CSF)标本中,急性CVD与DMD患者的MBP含量均明显升高,与OND患者比较均有显著性差异(P<0.05)。相关分析显示:急性CVD患者脑脊液和血清中MBP的含量之间呈正直线相关(r=0.72,P<0.01)。血清MBP含量与急性CVD的严重程度、意识障碍和肢体瘫痪的程度、CT扫描显示的脑损害程度和部位呈一致性。
The authors used double-antibody radioimmunoassay to detect the levels of myelin basic protein (MBP) in serum and cerebrospinal fluid in 34 patients with acute cerebrovascular disease (CVD), 30 with demyelinating disease (DMD) and 26 with other neurological disease (OND) MBP) were measured. The results showed that the average level of MBP and the positive rate of serum MBP in patients with acute CVD were significantly higher than those in patients with DMD and 0ND (P <0.06) .In CSF samples, MBP levels were significantly higher in patients with acute CVD and DMD Increased, compared with OND patients were significantly different (P <0.05). Correlation analysis showed that the levels of MBP in cerebrospinal fluid and serum of acute CVD patients were positively correlated (r = 0.72, P <0.01). Serum MBP levels correlated with the severity of acute CVD, the degree of disturbance of consciousness and limb paralysis, and the extent and location of brain damage as demonstrated by CT scans.