In this work, a UV-Visible light controlled supramolecular system based on ethyl cellulose(EC) was constructed, combining the host-guest interaction of β-cyclodextrin(β-CD) group and trans-isomer of azobenzene(tAzo) group. To link β-CD to the hydrophobic section, renewable EC was used as macroinitiator to initiate the polymerization of ε-caprolactone(ε-CL) to form biocompatible and biodegradable comb copolymer EC-g-PCL, and β-CD was attached to the end of PCL side chain via click reaction. Meanwhile, hydrophilic PEG-tAzo was obtained by N,N’-dicyclohexylcarbodiimide(DCC) coupling. Then, the structures of the products were characterized by nuclear magnetic resonance(NMR) and gel permeation chromatography(GPC). Subsequently, with the formation of inclusion complexes by β-CD and tAzo groups, the obtained EC-g-PCL-β-CD/PEG-tAzo supramolecular system self-assembled in water with hydrophobic EC-g-PCL-β-CD as core and hydrophilic PEG-tAzo as shell. Furthermore, dynamic light scattering(DLS) and transmission electron microscopy(TEM) were utilized to investigate the particle size and size distribution, while NMR and UV-Vis spectra were applied to explore the UV-Visible light stimuli-responsiveness of the micelles. In this work, a UV-Visible light controlled supramolecular system based on ethyl cellulose (EC) was constructed, combining the host-guest interaction of β-cyclodextrin (β-CD) group and trans-isomer of azobenzene (tAzo) group. To link β-CD to the hydrophobic section, renewable EC was used as macroinitiator to polymerize ε-caprolactone (ε-CL) to form biocompatible and biodegradable comb copolymer EC-g-PCL, and β-CD was attached to the end Then, the structures of the products were characterized by nuclear magnetic resonance (NMR) and gel permeation chromatography (GPC With the formation of inclusion complexes by β-CD and tAzo groups, the obtained EC-g-PCL-β-CD / PEG-tAzo supramolecular system self-assembled in water with hydrophobic EC-g-PCL- CD as core and hydrophilic PEG-tAzo as shell. Furthermore, dynamic light scatteri ng (DLS) and transmission electron microscopy (TEM) were utilized to investigate the particle size and size distribution, while NMR and UV-Vis spectra were applied to explore the UV-Visible light stimuli-responsiveness of the micelles.