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目的:探讨对比单纯使用干扰素或单纯使用LEEP,干扰素联合LEEP及对照组对CINⅠ的疗效观察。方法:选自CINI患者221例。根据自愿选择原则分为4组,第1治疗组使用干扰素治疗55例,第2治疗组单纯使用LEEP治疗53例,第3治疗组使用干扰素+LEEP治疗56例,第4组为对照组57例。结果:使用辛复宁组治疗1组及3组有效率为71%及85%,与未使用辛复宁组治疗2组及对照组对比,p<0.005,有统计学意义。对治疗CINⅠ的疗效中,治疗1组与对照组对比,p<0.005,有统计学意义。治疗2组与对照组对比,p<0.005,有统计学意义。治疗3组与对照组对比,p<0.005,有统计学意义。治疗3组与治疗1组对比,p<0.005,有统计学意义。治疗3组与治疗2组对比,p<0.005,有统计学意义。治疗1组与治疗2组对比,p>0.1,无统计学意义。结论:干扰素能有效地治疗宫颈持续性HPV感染,局部用药简单、方便、副反应少。对于宫颈上皮内瘤样病变用重组人干扰素α-2b联合LEEP治疗CINⅠ的疗效最佳,优于单纯的LEEP或单纯的辛复宁治疗,而用辛复宁及LEEP,或用辛复宁加LEEP均比对照组疗效好。辛复宁栓剂联合LEEP治疗CIN是一种安全、高效的治疗的方法,值得临床推广应用。
Objective: To compare the efficacy of simple interferon or simply using LEEP, interferon combined with LEEP and control group on CIN Ⅰ. Methods: 221 patients were selected from CINI patients. According to the principle of voluntary selection, the patients were divided into 4 groups: the first treatment group used 55 cases of interferon therapy, the second treatment group used LEEP alone in 53 cases, the third treatment group used interferon + LEEP in 56 cases, the fourth group was the control group 57 cases. Results: The effective rates of treatment group 1 and group 3 were 71% and 85%, respectively, which were significantly different from those of the control group and the untreated Xinfuning group (p <0.005). The treatment of CIN Ⅰ in the efficacy of treatment group 1 compared with the control group, p <0.005, with statistical significance. Treatment 2 groups compared with the control group, p <0.005, with statistical significance. Treatment 3 groups compared with the control group, p <0.005, with statistical significance. Treatment 3 groups and treatment group 1 contrast, p <0.005, with statistical significance. Treatment 3 groups and treatment group 2 contrast, p <0.005, with statistical significance. Treatment 1 group and treatment group 2 contrast, p> 0.1, no statistical significance. Conclusion: Interferon can effectively treat persistent cervical infection of the cervix. The topical administration is simple and convenient with few side effects. For cervical intraepithelial neoplasia with recombinant interferon α-2b combined with LEEP treatment of CIN Ⅰ the best, superior to simple LEEP or simple Xin Fu Ning treatment, and Xin Fu Ning and LEEP, or Xin Fu Ning and LEEP than the control group Good effect. Xin Fu Ning suppository combined with LEEP treatment of CIN is a safe and efficient treatment, it is worth clinical application.