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目的:探讨腹主动脉瘤(AAA)患者瘤腔内血栓(ILT)厚度及外周血中同型半胱氨酸(Hcy)与C反应蛋白(CRP)浓度的临床意义及相互关系。方法:选取2014年1月—2015年12月年间收治的AAA患者60例,以ELISA法测定外周血中Hcy浓度和CRP浓度,影像学方法测定ILT厚度。分析ILT厚度与临床因素的关系,以及ILT厚度、Hcy、CRP之间的相互关系。结果:厚ILT(厚度≥7.8mm)患者的高血压史比例、Hcy和CRP浓度明显高于薄ILT(厚度<7.8mm)患者(均P<0.05);相关分析显示,Hcy浓度与ILT厚度(r=0.942)、ILT厚度/AAA最大直径比值(r=0.844)、AAA最大直径(r=0.505)均呈明显正相关(均P<0.05),而CRP浓度与其他因素间均无相关(均P>0.05)。结论:ILT厚度、外周血Hcy与CRP浓度均可能是AAA进展的危险因素,且ILT厚度与Hcy浓度之间可能存在相互促进的关系。
Objective: To investigate the clinical significance and relationship between the thickness of tumor thrombus (ILT) and homocysteine (Hcy) and C-reactive protein (CRP) in patients with abdominal aortic aneurysm (AAA). Methods: Sixty patients with AAA were selected from January 2014 to December 2015, Hcy concentration and CRP concentration in peripheral blood were determined by ELISA, ILT thickness was measured by imaging method. The relationship between ILT thickness and clinical factors and the relationship between ILT thickness, Hcy and CRP were analyzed. Results: The history of hypertension, Hcy and CRP in patients with thick ILT (thickness≥7.8mm) were significantly higher than those with thin ILT (thickness <7.8mm) (all P <0.05). Correlation analysis showed that Hcy concentration was positively correlated with ILT thickness r = 0.942), the ratio of ILT thickness / AAA maximum diameter (r = 0.844), AAA maximum diameter (r = 0.505) were positively correlated (all P <0.05), while there was no correlation between CRP concentration and other factors P> 0.05). CONCLUSION: The thickness of ILT, the concentrations of Hcy and CRP in peripheral blood may be the risk factors for the progression of AAA, and the relationship between ILT thickness and Hcy concentration may be mutually reinforcing.