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目的 探讨我国不同地区医院获得性感染 (HAI)和社区获得性感染 (CAI)患者中革兰阳性球菌耐药情况。方法 按原设计方案对 13家医院从 2 0 0 0年 7月 1日至 2 0 0 1年 6月 30日年度内分离的 2 40 1株致病菌中的 80 5株革兰阳性球菌采用国际标准平皿二倍稀释法进行体外敏感试验 ,按2 0 0 1年美国临床实验标准委员会 (NCCLS)指导原则的标准 ,测得最低抑菌浓度 (MIC50 )、MIC90 表示抗菌药物的抗菌活性 ,并计算出所测细菌对抗菌药物的耐药率 (R % )、中介率 (I% )和敏感率 (S % )。结果 从住院感染患者中分离到 2 38株金黄色葡萄球菌 ,甲氧西林耐药金黄色葡萄球菌 (MRSA)与甲氧西林耐药表皮葡萄球菌 (MRSE)的检出率分别为 37 4% ( 89/ 2 38)和 33 8% ( 5 1/ 15 1)。其中从CAI患者与HAI患者中分离的金黄色葡萄球菌数分别为 139株和 37株 (另有 6 2株不明确是CAI还是HAI)。HAI患者中MRSA检出率为 89 2 % ( 33/ 37) ,显著高于CAI患者中MRSA检出率 30 2 % ( 42 / 139) (P <0 0 1)。青霉素耐药肺炎链球菌 (PRSP)的检出率 (R % +I% )为 3 3 % ( 1/ 30 ) +2 3 3% ( 7/ 30 ) ,总耐药率为 2 6 6 % ( 8/ 30 )。从研究病房分离到肠球菌 178株 ,非研究病房分离到 15 3株 ,共计 331株。其中粪肠球菌 2 86株、屎肠球?
Objective To investigate the drug-resistance of Gram-positive cocci in hospital-acquired (HAI) and community-acquired (CAI) patients in different areas in China. Methods According to the original design, 805 strains of Gram-positive cocci isolated from 2401 pathogens isolated in 13 hospitals from July 1, 2000 to June 30, 2001 were analyzed by International The standard plate two-fold dilution method for in vitro sensitivity test, according to the 2001 United States Clinical Trial Standards Committee (NCCLS) guidelines, the minimum inhibitory concentration (MIC50), MIC90 said antimicrobial antibacterial activity, and calculated The antibacterial resistance rate (R%), the mediation rate (I%) and the sensitivity rate (S%) of the bacteria tested were determined. Results A total of 238 strains of Staphylococcus aureus were isolated from hospitalized patients. The detection rates of methicillin - resistant Staphylococcus aureus (MRSA) and methicillin - resistant Staphylococcus epidermidis (MRSE) were 37.4% 89/2 38) and 33 8% (5 1/15 1). Among them, the number of Staphylococcus aureus isolated from CAI patients and HAI patients were 139 strains and 37 strains, respectively (62 other strains were not clearly identified as CAI or HAI). The detection rate of MRSA in HAI patients was 89.2% (33/37), which was significantly higher than that of CAI patients (30.2% (42/139)) (P <0.01). The detection rate of penicillin-resistant Streptococcus pneumoniae (PRSP) was 33% (1/30) + 23 3% (7/30), and the total resistance rate was 26.6% (R% + I% 8/30). 178 Enterococcus isolates were isolated from research wards and 153 were isolated from non-research wards for a total of 331 strains. Which Enterococcus faecium 2 86 strains, feces intestinal?