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60例育龄妇女服复方炔雌醚(简称复雌片)4～13年,血浆皮质醇水平明显升高(27.72±1.05μg/100ml)与正常对照组(15.63±0.60μg/100ml)及曾短期服用短效避孕药组(19.76±0.86μg/100ml)相比,差异均具有非常显著意义。复雌片组口服葡萄糖耐量试验(OGTT)各时相的血糖值与正常对照组近似。本文结果提示复雌片避孕药对肾上腺皮质功能的影响,可能是通过负反馈机制引起垂体前叶ACTH分泌减少,因而皮质醇水平升高。较低剂量的复雌片对糖代谢无明显影响。
60 cases of women of childbearing age were treated with compound ethynylestradiol for 4 ~ 13 years, the level of plasma cortisol was significantly increased (27.72 ± 1.05μg / 100ml) compared with the control group (15.63 ± 0.60μg / 100ml) Compared with the short-acting contraceptives group (19.76 ± 0.86μg / 100ml), the difference was very significant. Oral glucose tolerance test (OGTT) in each phase group was similar to that of the normal control group. Our results suggest that the effect of the compound pill on the adrenocortical function may be caused by the negative feedback mechanism leading to anterior pituitary ACTH secretion decreased, and thus increased cortisol levels. The lower dose of the compound female tablets on glucose metabolism had no significant effect.