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目的 探讨肾上腺髓质素前体N端 2 0肽 (PAMP)的心血管效应以及原发性高血压(EH)患者血浆PAMP的浓度变化。方法 静注PAMP ,观察其对大鼠的血压、心率、左室收缩峰压及舒张血管平滑肌的作用。用放免法测定EH患者的血浆PAMP浓度。结果 PAMP可以降低大鼠血压和舒张大鼠主动脉环张力 ,并呈剂量依赖性 ;EH患者血浆PAMP含量〔(30 .6 0± 2 .2 6 )ng/L〕明显高于对照组〔(18.41± 2 .33)ng/L ,P <0 .0 1〕 ,随病期的加重升高更明显 (P均 <0 .0 1) ,与平均动脉压呈正相关 (r=0 .431,P <0 .0 5 )。结论 PAMP是一种舒血管肽 ;EH患者血浆PAMP浓度升高可能是机体维持自稳态的一种保护性代偿机制
Objective To investigate the cardiovascular effects of adrenomedullin precursor N-terminal 20 peptide (PAMP) and the plasma PAMP concentration in patients with essential hypertension (EH). Methods PAMP was injected intravenously to observe its effect on blood pressure, heart rate, peak pressure of left ventricular systolic and vasodilator smooth muscle in rats. Plasma PAMP concentration was measured by radioimmunoassay in patients with EH. Results PAMP could decrease the aortic ring tension of rats in a dose-dependent manner. The plasma PAMP level in EH patients 〔(30.60 ± 2.26) ng / L〕 was significantly higher than that in the control group 〔(( 18.41 ± 2.33) ng / L, P <0.01), with the increase of disease stage more obviously (all P <0.01), and mean arterial pressure was positively correlated (r = 0.431, P <0. 05). Conclusions PAMP is a kind of vasopressin. The increase of plasma PAMP concentration in EH patients may be a kind of protective compensatory mechanism for the body to maintain self-homeostasis