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目的探讨胃肠道间质瘤(gastrointestinal stromal tumors,GIST)的临床病理特点及诊治情况。方法对31例GIST患者的临床资料进行回顾性分析。结果全部患者均行手术治疗。31例GIST患者发生部位以胃(19例,61.35%)和空肠(6例,19.3%)为主。首发症状以腹痛、腹胀(20例,64.5%)和消化道出血(12例,38.7%)、腹部包块(8例,25.8%)为主要表现。病理报告良性13例,潜在恶性2例,恶性16例。免疫组化CD117阳性28例(90.3%),CD34阳性26例(83.9%)。结论(1)GIST消化道症状无特异性,术前确诊率低,易造成误诊。(2)CD117和CD34阳性可以作为GIST的诊断标志。(3)治疗应以局部切除为主,恶性者应扩大切除范围。
Objective To investigate the clinicopathological characteristics and diagnosis and treatment of gastrointestinal stromal tumors (GIST). Methods The clinical data of 31 patients with GIST were retrospectively analyzed. Results All patients underwent surgical treatment. Twenty-one patients with GIST were mainly stomach (19 cases, 61.35%) and jejunum (6 cases, 19.3%). The first symptom was abdominal pain, bloating (20 cases, 64.5%) and gastrointestinal bleeding (12 cases, 38.7%), abdominal mass (8 cases, 25.8%) as the main performance. Pathological report of benign in 13 cases, 2 cases of potential malignant, malignant 16 cases. Immunohistochemical CD117 positive in 28 cases (90.3%), CD34 positive in 26 cases (83.9%). Conclusions (1) GIST gastrointestinal symptoms are nonspecific, and the preoperative diagnosis rate is low, which can easily lead to misdiagnosis. (2) CD117 and CD34 positive can be used as a diagnostic marker of GIST. (3) The treatment should be based on local excision, malignant should expand the scope of resection.