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本文对14例骨髓异常增生综合征(MDS)的骨髓染色体核型和不稳定性进行了分析。染色体异常发生率为43％,异常克隆涉及第9、21、20、4和12及19号与X染色体8例病人于染色体不稳定组。本文讨论了MDS患者细胞遗传学改变的临床意义,提出除了核型改变外染色体不稳定性分析对MDS预后的判断也是一项有价值的指标。
In this paper, 14 cases of myelodysplastic syndrome (MDS) bone marrow chromosome karyotype and instability were analyzed. The incidence of chromosomal abnormalities was 43%. Abnormal clones involved chromosomes 9, 21, 20, 4 and 12 and 19 with chromosome X in 8 patients with chromosomal instability. This article discusses the clinical significance of cytogenetic changes in patients with MDS and suggests that in addition to karyotypic changes in chromosomal instability analysis of the prognosis of MDS is also a valuable indicator.