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目的:考察混合糖电解质注射液(新海能)与16种常用药物配伍的稳定性,供临床用药参考。方法:模拟临床常用浓度和配制方法,对16种常用药物与新海能配伍后外观、pH值、含量、微粒变化等指标进行观察研究。结果:新海能配伍头孢呋辛在6h内pH值无明显变化,24h时pH值有所升高;随着时间的延长,配伍注射用亚胺培南/西司他定溶液的颜色逐步加深;配伍替考拉宁后有气泡产生,其余药物配伍后在24h内各指标均无明显变化。结论:头孢呋辛配伍后应在6h内用完,在临床上不建议亚胺培南/西司他定及替考拉宁与新海能配伍,其余13种药物配伍稳定性较好。
Objective: To investigate the compatibility of mixed sugar and electrolyte injection (Xinhai) with 16 kinds of commonly used drugs for clinical reference. Methods: To simulate the common clinical concentrations and preparation methods, the appearance, pH value, content and particle changes of 16 commonly used drugs and Xinhai N were observed and studied. Results: The pH value of Xinhai Nepheloxime with cefuroxime did not change significantly within 6h, and the pH value increased at 24h. With the extension of time, the color of compatibility imipenem / cilastatin solution gradually deepened; After teicoplanin compatibility with bubbles, the rest of the drug compatibility within 24 hours after no significant change in each indicator. Conclusion: Cefuroxime should be used within 6h after compatibility. Imipenem / cilastatin and teicoplanin are not recommended to be combined with Xinhai Neng in clinical practice. The stability of the other 13 drugs is good.