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阿朴吗啡是一种多巴胺受体直接兴奋剂,对缓解震颤麻痹的症状有效。但因其作用时间短和副作用较多,使临床应用受到了限制。作者用盐水(2ml,肌注)或domperidone(100μg/kg,肌注)分别在阿朴吗啡(20μg/kg,肌注)应用前60分钟给予,各自联合对4例震颤麻痹患者进行双盲对照试验。结果盐水与阿朴吗啡联合应用后,症状显著减轻,平均改善33.8%,但4例均产生倦睡,3例有恶心和不适,血压下降和打哈欠者各2例。这些副作用在阿朴吗啡用后数分钟内出现,持续40分钟,于用药后15～20分钟最显著。而domperidone与阿朴吗啡联合应用后,除3例打哈欠外,未出现任何副作用。
Apomorphine is a dopamine receptor direct stimulant and is effective in relieving the symptoms of Parkinson’s paralysis. However, due to its short acting time and side effects, the clinical application has been limited. The patients were given saline (2 ml intramuscularly) or domperidone (100 μg / kg intramuscularly) respectively 60 minutes before apomorphine (20 μg / kg, intramuscular injection) for application. Four pairs of patients with tremor paralysis test. Results After the combination of saline and apomorphine, the symptoms were significantly relieved, with an average improvement of 33.8%. However, all the 4 patients had drowsiness, 3 had nausea and discomfort, and 2 patients had blood pressure drop and yawning. These side effects appear apomorphine within minutes after taking 40 minutes, 15 to 20 minutes after the most significant medication. And domperidone and apomorphine combined application, in addition to 3 cases of yawning, there is no side effects.