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目的:探讨神经白塞氏病(NBD)的临床特征及诊治方法。方法:收集本院风湿科从2005年至2014年收治的13例NBD患者,回顾性分析患者的临床资料。结果:NBD临床表现包括头痛(9例),发热(7例),精神症状(4例),肢体瘫痪、麻木(3例),共济失调(2例),构音障碍(1例)及眩晕(1例)。头颅MRI提示病变部位主要分布在中脑(5例)、脑桥(2例)及基底节区(2例)。患者均给予糖皮质激素免和疫抑制剂后症状缓解。结论:NBD预后较差,为白塞氏病的重症表现之一。了解NBD的临床特征,有利于对该类患者进行及早的诊断与治疗。
Objective: To investigate the clinical features and diagnosis and treatment of neurobending disease (NBD). Methods: Thirteen patients with NBD admitted to our department from 2005 to 2014 were retrospectively analyzed. Results: The clinical manifestations of NBD included headache (9 cases), fever (7 cases), psychiatric symptoms (4 cases), limb paralysis, numbness (3 cases), ataxia (2 cases), dysarthria (1 case) Dizziness (1 case). Head MRI showed that the lesion mainly distributed in midbrain (5 cases), pons (2 cases) and basal ganglia (2 cases). Patients were given glucocorticoids and immunosuppressive agents to relieve symptoms. Conclusion: The prognosis of NBD is poor, which is one of the severe manifestations of Behcet’s disease. To understand the clinical features of NBD is conducive to such patients for early diagnosis and treatment.