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目的:研究饮用水微囊藻毒素(MC)与恶性肿瘤死亡率的关系。方法:在江苏无锡选取10个饮水类型不同的乡镇或街道作为调查点开展一项生态流行病学研究。收集1992-2000年各调查点恶性肿瘤的死亡资料,同时采集不同类型水样,综合评价各调查点MC的暴露水平。分析MC暴露等级与恶性肿瘤死亡率的相关关系。结果:饮用水MC暴露等级与男性胃癌和男性各部位合计恶性肿瘤的直接和间接标化死亡率呈现正相关;与男性肠癌的直接标化死亡率呈现负相关(P<0.05);未发现MC与女性恶性肿瘤标化死亡率、人群截缩标化死亡率之间存在相关(P>0.05)。结论:饮水MC污染可能与无锡地区男性恶性肿瘤死亡率,尤其是胃癌死亡率的上升有关。
Objective: To study the relationship between microcystin (MC) in drinking water and the mortality of malignant tumor. METHODS: Ten ecotope studies were conducted in Wuxi, Jiangsu Province, using 10 villages or towns of different types of drinking water as survey points. The data of death from malignant tumors at each survey point from 1992 to 2000 were collected. At the same time, different types of water samples were collected, and the exposure level of MC at each survey point was comprehensively evaluated. The relationship between MC level of exposure and malignant tumor mortality was analyzed. Results: There was a positive correlation between the level of MC exposure in drinking water and the total and directly normalized mortality rate of malignant tumors in all groups of male and female gastric cancer patients. There was a negative correlation between the direct and indirect mortality rates of male patients with colorectal cancer (P <0.05). There was a correlation between MC and the standardized mortality rate of female malignant tumors and the truncated standardized mortality rate (P> 0.05). Conclusion: The drinking water MC pollution may be related to the male malignant tumor mortality in Wuxi area, especially the increase of gastric cancer mortality.