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目的了解深圳市龙岗区儿童肠道病毒71型(EV71)抗体水平及自然感染状况,为预防控制儿童手足口病传播与流行提供依据。方法 2012年6月采集528名0～5岁儿童血清标本,采用酶联免疫法检测血清中的EV71IgG。结果 2008～2011年深圳市龙岗区共报告手足口病28 847例,年龄11d～50岁,5岁以下幼儿占总病例数的89.40%(25789/例)。528名儿童中EV71IgG抗体阳性241例,阳性率为45.64%;<1岁龄的婴儿IgG抗体阳性率最低;男童IgG抗体阳性率为46.18%,女童为44.93%,差异无统计学意义(χ2=0.37,P>0.05)。结论 5岁以下幼儿特别<1岁龄的婴儿是应手足口病防控的重点人群。
Objective To understand the antibody level and natural infection of EV71 in children in Longgang District, Shenzhen, and to provide basis for prevention and control of the spread and epidemic of HFMD in children. Methods Serum samples of 528 children aged 0-5 years were collected in June 2012, and serum EV71 IgG was detected by enzyme-linked immunosorbent assay. Results From 2008 to 2011, a total of 28 847 HFMD cases were reported in Longgang District, Shenzhen City. A total of 28789 cases were aged 11 to 50 years old and children under 5 years old accounted for 89.40% of the total number of cases. There were 241 positive cases of EV71 IgG antibody in 528 children, the positive rate was 45.64%. The positive rate of IgG antibodies in infants younger than 1 year was the lowest. The positive rate of IgG was 46.18% in boys and 44.93% in girls, with no significant difference (χ2 = 0.37, P> 0.05). Conclusions Infants under 5 years of age, especially <1 year old, are the key people who should be given prevention and control of HFMD.