AIM:Non-bioartificial liver has been applied to clinic forquite a long time,but the reported efficacy has been verydifferent.The aim of this study was to compare the efficacyand safety of hemoperfusion adsorption,plasma exchangeand plasma exchange plus hemoperfusion adsorption intreatment of severe viral hepatitis.METHODS:Seventy-five patients with severe viral hepatitiswere treated with hemoperfusion adsorption therapy(24cases),plasma exchange therapy(17 cases)and plasmaexchange plus hemoperfusion adsorption therapy(34 cases).The data of liver function,renal function,blood routine test,prothrombin time(PT)and prothrombin activity(PTa)pre-and post-therapy were analyzed.RESULTS:Clinical symptoms of patients improved aftertreatment.The levels of aminotransferase,total bilirubin,direct bilirubin decreased significantly after 3 therapies(P<0.05 or P<0.01).PT,the level of total serum proteindecreased significantly and PTa increased significantly afterplasma exchange therapy and plasma exchange plushemoperfusion adsorption therapy(P<0.05 or P<0.01).Theside effects were few and mild in all patients.CONCLUSION:Three therapies were effective in thetreatment of severe viral hepatitis.Plasma exchange therapyand plasma exchange plus hemoperfusion adsorption therapyare better than hemoperfusion adsorption therapy. AIM: Non-bioartificial liver has been applied to clinic forquite a long time, but the reported efficacy has been very different. The aim of this study was to compare the efficacy and safety of hemoperfusion adsorption, plasma exchange and plasma exchange plus hemoperfusion adsorption intreatment of severe viral five patients with severe viral hepatitiswere treated with hemoperfusion adsorption therapy (24cases), plasma exchange therapy (17 cases) and plasmaexchange plus hemoperfusion adsorption therapy (34 cases). data of liver function, renal function, blood routine RESULTS: Clinical symptoms of patients improved aftertreatment. These levels of aminotransferase, total bilirubin, direct bilirubin decreased significantly after 3 therapies (P <0.05 (test), prothrombin time (PT) and prothrombin activity or P <0.01) .PT, the level of total serum protein decreased significantly and PTa increased significantly afterplasma exchange therapy and plasma excha Tachide effects were few and mild in all patients. CONCLUSION: Three therapies were effective in the treatment of severe viral hepatitis. Plasma exchange therapy and plasma exchange plus hemoperfusion adsorption therapy better than hemoperfusion adsorption therapy.