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目的:观察尼莫地平(Nim),非洛地平(Fel)是否有不同的作用模式.方法:比较尼莫地平(Nim),非洛地平(Fel)对去甲肾上腺素(NE)和氯化钙(CaCl_2)引起的人动脉收缩的不同作用,并且与维拉帕米(Ver)的作用相比较.结果:Nim,Fel和Ver对无Ca~(2+)高K~+去极化时CaCl_2所致离体人血管收缩的拮抗作用比其对NE引起收缩拮抗作用强。在CaCl_2引起收缩时,Nim,Fel和Ver拮抗作用pD_2~′在子宫动脉分别为7.50,7.42,6.35;在肠系膜动脉分别为7.38,7.65和7.20;在肾动脉分别为7.87,9.10和7.32,Ver可抑制NE所致的两种收缩成分,Nim或Fel仅抑制外Ca~(2+)内流引起收缩.结论:Fel对肾血管有选择作用.
OBJECTIVE: To observe whether Nim and Fel had different modes of action.Methods: The effects of nim and felodipine on norepinephrine (NE) and chloride Calcium (CaCl 2) -induced contraction of human arteries, and compared with the effect of verapamil (Ver) .Results: When Nim, Fel and Ver were devoid of Ca 2+ -dependent K + Antagonism of isolated human vasoconstriction by CaCl 2 was stronger than that of NE-induced contractions. The antagonistic effect of Nim, Fel and Ver was 7.50, 7.42 and 6.35 respectively in the uterine artery, 7.38, 7.65 and 7.20 in the mesenteric artery, 7.87, 9.10 and 7.32 in the renal artery, respectively Can inhibit the contraction of the two components of NE, Nim or Fel only inhibit Ca2 + influx induced contraction.Conclusion: Fel on the role of renal blood vessels.