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本实验观察了两种不同炮制方法的甘草对大鼠肾上腺内维生素C与胆固醇含量的影响及其急性毒性。实验表明,用蜜炙的炒甘草或烘甘草灌胃3天后,大鼠肾上腺内维生素C和胆固醇含量有相似的下降,与对照组比较,差异显著(p<0.01),表现为促皮质激素样作用;伍用地塞米松后,炒甘草与烘甘草对肾上腺内维生素C和胆固醇含量有相似的减少,表现为拮抗地塞米松对丘脑—垂体—肾上腺皮质轴的抑制作用。急性毒性试验表明,炒甘草煎剂的小鼠口服LD_(50)为23.9ml/kg(相当于生药23.9g);烘甘草煎剂的LD_(50)为41.7ml/kg(相当于生药41.7g);炒甘草毒性大于烘甘草;两者比较,有显著差异(p<0.05)。
This experiment observed the effects of licorice from two different processing methods on the content of vitamin C and cholesterol in the adrenal gland of rats and its acute toxicity. Experiments showed that the contents of vitamin C and cholesterol in the adrenal glands of rats decreased similarly after intragastric administration of candied licorice or dried licorice for 3 days. There was a significant difference (p<0.01) between the adrenal glands of the rats and the control group. Effects; after using dexamethasone, fried licorice and dried licorice had a similar reduction in the content of vitamin C and cholesterol in the adrenal glands, manifested as an antagonist of dexamethasone on the thalamus - pituitary - adrenal cortex axis inhibition. Acute toxicity test showed that the oral LD_(50) was 23.9 ml/kg (equivalent to 23.9 g of crude drug) in the mice of the fried licorice decoction; the LD_(50) of the dried licorice decoction was 41.7 ml/kg (equivalent to 41.7 g of crude drug). ); The toxicity of fried licorice is greater than that of dried licorice; there is a significant difference between the two (p<0.05).