目的研究小茴香对大鼠肝纤维化及脂质过氧化的影响。方法取Wistar大鼠100只,随机取12只设为正常对照组,其余采用四氯化碳(CCl4)复合因素法复制肝纤维化大鼠模型,模型复制成功后随机分为模型对照组、小茴香低、中、高剂量组和复方丹参组,每组12只;相应药物干预8周后,镜检肝组织形态学改变;全自动生化分析仪检测外周血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)水平与血清总蛋白(TP)、白蛋白(ALB)含量;生化法检测血清及肝组织中羟脯氨酸(HYP)与丙二醛(MDA)含量及超氧化物歧化酶(SOD)活性。结果 HE结果显示:模型对照组肝脏组织炎症与脂肪变性明显,经小茴香不同剂量干预后明显改善。生化检测结果显示:与正常对照组比较,模型对照组ALT、AST水平显著升高(P<0.05),TP、ALB含量显著降低(P<0.05),HYP、MDA含量显著增加(P<0.05),SOD活性显著降低(P<0.05);与模型对照组比较,小茴香低、中、高剂量组和复方丹参组ALT、AST水平显著下降(P<0.05),TP、ALB水平显著升高(P<0.05);HYP、MDA含量显著降低(P<0.05),SOD活性显著提高(P<0.05)。结论小茴香具有良好的抗肝纤维化作用,其作用机制可能与调节大鼠脂质过氧化水平有关。 Objective To study the effects of cumin on hepatic fibrosis and lipid peroxidation in rats. Methods A total of 100 Wistar rats were randomly divided into normal control group (n = 12) and CCl4 composite model. The model rats were randomly divided into model control group The low, medium and high dose fennel group and compound salvia miltiorrhiza group, each group of 12; corresponding drug intervention for 8 weeks, microscopic examination of liver morphology; automatic biochemical analyzer detection of peripheral serum alanine aminotransferase (ALT), day AST and serum total protein (TP) and albumin (ALB) were detected by spectrophotometry. The contents of hydroxyproline (HYP) and malondialdehyde (MDA) Dismutase (SOD) activity. Results The results of HE showed that the liver tissue inflammation and steatosis of the model control group were significantly improved, and were significantly improved after intervention with different doses of fennel. The results of biochemical tests showed that the levels of ALT and AST were significantly increased (P <0.05), the levels of TP and ALB were significantly decreased (P <0.05) and the levels of HYP and MDA were significantly increased (P <0.05) in the model control group compared with the normal control group (P <0.05). Compared with the model control group, the levels of ALT and AST in the low, medium and high dose fenvalerate groups and the compound salvia miltiorrhiza group were significantly decreased (P <0.05), and the levels of TP and ALB were significantly increased P <0.05). The levels of HYP and MDA were significantly decreased (P <0.05) and SOD activity was significantly increased (P <0.05). Conclusion Fennel has a good anti-hepatic fibrosis effect and its mechanism may be related to the regulation of lipid peroxidation in rats.