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目的:探讨p53及PCNA蛋白在所谓肺硬化性血管瘤(so-ca lled pu lm onary scleros ing hem ang iom a,PSH)组织中的表达及意义。方法:应用免疫组化S-P法,检测35例PSH、8例肺炎性假瘤(pu lm onary pseudotum or,PP)、8例正常肺组织(norm a l lung tissue,NL)中p53和PCNA的蛋白表达。结果:p53及PCNA蛋白在35例PSH组织中的阳性表达率分别为45.71%(16/35)和62.86%(22/35),在8例PP组织中的阳性表达率分别为0%(0/8)和25%(2/8),而8例NL组织中均呈阴性表达。p53、PCNA在PSH组织的阳性表达率显著高于NL和PP组织(P<0.05)。结论:p53、PCNA蛋白的过表达可能与PSH发生发展有关。
Objective: To investigate the expression and significance of p53 and PCNA protein in so-called cirrhosis of the liver (PSH). Methods: Immunohistochemical SP method was used to detect the protein expression of p53 and PCNA in 35 cases of PSH, 8 cases of pulmonary pseudotumor (PP), 8 cases of norm al lung tissue (NL) . Results: The positive rates of p53 and PCNA in 35 cases of PSH were 45.71% (16/35) and 62.86% (22/35), respectively. The positive rates of p53 and PCNA in 8 cases of PP were 0% (0 / 8) and 25% (2/8), respectively. However, all of the 8 cases of NL tissues were negative. The positive rates of p53 and PCNA in PSH tissues were significantly higher than those in NL and PP tissues (P <0.05). Conclusion: The overexpression of p53 and PCNA may be related to the development of PSH.