论文部分内容阅读
目的:探讨外周血白细胞计数与血压水平的关系。方法:采用横断面研究方法,从门诊及体检人群中随机抽查1 136例为研究对象。根据血压水平按JNC-7标准将其分为3组:正常血压组497例(≤120/80mmHg)、高血压前期组258例(130~139/85~89mmHg)、高血压组371例(≥140/90mmHg)。通过问卷调查及体检获取一般资料,包括年龄、性别、病史、用药史、家族史等,测量其身高、体重、血压水平,检测外周血白细胞计数、血脂谱、血尿酸、血肌酐及尿素氮等。结果:不同外周血白细胞计数组高血压的发生率不同,随着外周白细胞水平增加其血压水平逐渐增加(P<0.01)。相关分析显示,无论男性或女性,白细胞计数与收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、体质量指数(BMI)、三酰甘油(TG)相关(P<0.01)。Logistic多元回归分析显示,在调整了年龄、性别、BMI、腰围、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血肌酐、血尿酸、尿素氮及空腹血糖后,白细胞计数的最高四分位组发生高血压的危险性是白细胞计数最低组的2.1倍(P<0.01),且高血压的危险性随白细胞计数的增加而增加(P<0.01)。多元线性回归显示,外周血白细胞计数是MAP、SBP及DBP的独立危险因素(P<0.01)。结论:外周血白细胞计数与血压水平密切相关,且这种作用独立于其他多重危险因素。
Objective: To investigate the relationship between peripheral blood leukocyte count and blood pressure level. Methods: A cross-sectional study was conducted to randomly select 1 136 cases from the outpatient and physical examination groups as study subjects. According to the blood pressure level, they were divided into 3 groups according to JNC-7 standard: 497 cases (≤120 / 80mmHg) in normal blood pressure group, 258 cases (130 ~ 139/85 ~ 89mmHg) in prehypertensive group, 371 cases 140 / 90mmHg). General information such as age, gender, medical history, medication history and family history were obtained through questionnaire and physical examination. The height, weight, blood pressure level, peripheral blood leucocyte count, blood lipid profile, serum uric acid, serum creatinine and urea nitrogen were measured . Results: The incidences of hypertension in different peripheral blood leukocyte count groups were different. The blood pressure level increased gradually with the increase of peripheral leukocyte count (P <0.01). Correlation analysis showed that white blood cell count was correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), body mass index (BMI) and triglyceride (TG) . Logistic multiple regression analysis showed that after adjusting for age, sex, BMI, waist circumference, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, serum creatinine, serum uric acid, urea nitrogen and fasting blood glucose, The risk of developing hypertension in the highest quartile of patients was 2.1-fold (P <0.01) higher than that in the lowest group, and the risk of hypertension was increased with an increase in leukocyte count (P <0.01). Multiple linear regression showed that peripheral blood leukocyte count was an independent risk factor of MAP, SBP and DBP (P <0.01). Conclusion: Peripheral blood leukocyte count is closely related to blood pressure level, and this effect is independent of other multiple risk factors.