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目的探讨P选择素(Ps)的变化与冠心病(CHD)发病和病情变化的关系。方法选择冠心患者85例,其中稳定型心绞痛(SAP)30例,不稳定型心绞痛(UAP)35例,急性心肌梗死(AMI)20例。另选30例正常人为对照。测定血清Ps水平,比较各组间差异并作相关性分析。结果冠心病组Ps水平均高于正常组(P<0.01),UAP组、AMI组Ps水平明显高于SAP组。结论Ps水平有助于CHD的发病和病变程度的判断。
Objective To investigate the relationship between the changes of P-selectin (Ps) and the incidence of coronary heart disease (CHD) and its changes. Methods Eighty-five patients with coronary heart disease were selected, including 30 cases of stable angina pectoris (SAP), 35 cases of unstable angina pectoris (UAP) and 20 cases of acute myocardial infarction (AMI). Another 30 cases of normal control. Serum Ps levels were measured, and the differences between groups were compared and analyzed. Results The levels of Ps in CHD group were significantly higher than those in normal group (P <0.01). The levels of Ps in UAP group and AMI group were significantly higher than those in SAP group. Conclusions The level of Ps contributes to the diagnosis of CHD and the degree of lesion.