[目的]探讨NET-1蛋白在肺癌中的表达及临床病理意义。[方法]免疫组化法检测63例肺癌中NET-1蛋白的表达,分析NET-1表达与临床因素及预后的关系。[结果]NET-1表达与肺癌分化程度、TNM分期和淋巴结转移有关(P分别为0.001、0.003和0.003),与患者的性别、年龄、肿瘤大小、病理类型、临床分型无关(P>0.05)。NET-1弱阳性表达组的生存优于强阳性表达组(χ2=10.603,P=0.001)。[结论]NET-1在肺癌中高表达,其表达与肺癌预后相关。 [Objective] To investigate the expression of NET-1 protein in lung cancer and its clinicopathological significance. [Method] The expression of NET-1 in 63 cases of lung cancer was detected by immunohistochemistry. The relationship between the expression of NET-1 and clinical factors and prognosis was analyzed. [Results] The expression of NET-1 was correlated with the degree of lung cancer differentiation, TNM stage and lymph node metastasis (P 0.001,0.003 and 0.003 respectively), but not with the gender, age, tumor size, pathological type and clinical type ). The survival of weak positive expression group of NET-1 was better than strong positive expression group (χ2 = 10.603, P = 0.001). [Conclusion] NET-1 is highly expressed in lung cancer and its expression is related to the prognosis of lung cancer.