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肝细胞肝癌（HCC）手术后容易复发转移，是其预后较差的主要原因。作者通过39例HCC瘤体与切缘的流式细胞仪分析（FCM）发现，瘤体异倍体出现率89．75％，切缘异倍体出现率54．29％，切缘异倍体有48．57％与瘤体不一致。结果提示，瘤体出现异倍体，肿瘤的恶性程度高，预后差，尤其是低二倍体与多异倍体的出现，预后更差。切缘出现异倍体，预后放二倍体差，出现多异倍体更差。根据不同的DNA指数是肿瘤的不同起源的理论，进一步证实HCC既存在“单中心起源”，又存在“多中心起源”，这对HCC预后的判断与临床治疗有一定的帮助。
Hepatocellular carcinoma (HCC) is easy to relapse and metastasis after surgery, which is the main reason for its poor prognosis. By flow cytometric analysis (FCM) of 39 HCC tumors and margins, the authors found that the incidence of aneuploidy was 89.75%, the incidence of aneuploidy was 54.29%, and the margin was aneuploid. 48.57% were not consistent with the tumor. The results suggest that the tumor appears aneuploid, the tumor has a high degree of malignancy, and the prognosis is poor, especially the appearance of low diploid and polyploids, and the prognosis is even worse. Aneuploidy appeared at the margin, the prognosis was diploid and the polyploid was worse. According to the different DNA index is the theory of different origins of tumors, it is further confirmed that HCC has both “single center origin” and “multi-center origin”, which is helpful to the prognosis of HCC and clinical treatment.