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肾素-血管紧张素系统在控制血压和调节肾功能中起着重要作用。近代研究表明,血管紧张素转化酶抑制剂很有希望用于治疗高血压疾病。血管紧张素转化酶能使十肽的血管紧张素I羧酸端的二肽断裂,生成具有强力收缩血管作用的血管紧张素II,同时它还能促使血管舒缓素失活。所以血管紧张素转化酶抑制剂能显示出抗高血压作用。目前临床应用的有壬肽抗压素(SQ 20881)和巯甲丙脯酸(Captopril,SQ 14225)。由于SQ 14225有皮疹副作用,所以作者设想用其它弱的Zn~(++)螯合基团代替
The renin-angiotensin system plays an important role in controlling blood pressure and regulating renal function. Modern research shows that angiotensin-converting enzyme inhibitors are promising for the treatment of hypertension. Angiotensin-converting enzyme cleaves the dipeptide of the decapeptide at the carboxylic acid end of angiotensin I, producing angiotensin II with a potent vasoconstrictor effect and inactivating it at the same time. So angiotensin converting enzyme inhibitors can show antihypertensive effect. Non-peptide antibiotics (SQ 20881) and captopril (SQ 14225) are currently used clinically. Since SQ 14225 has skin rash side effects, the authors envisaged replacing other weak Zn ~ (++) chelating groups