为了防止有感染性的羊痒疫和牛海绵样脑病(BSE)的动物或材料的传播乃至进入食物链,亟需设法建立有效的控制和消灭措施,但由于诊断的困难而受影响。以往采用组织病理学方法检查动物中枢神经系统典型的海绵样变,这病变须在疾病发展到晚期才能显示,无法在临床症状出现前及早发现。本文报道了一种从感染羊痒疫小鼠的脑、脾组织粗提液中检出PrP~(SC)的高度敏感 In order to prevent the spread of infectious or even scrapie and bovine spongiform encephalopathy (BSE) animals or materials into the food chain, there is an urgent need to find effective control and elimination measures that are affected by the difficulties of diagnosis. In the past, histopathology was used to examine typical sponge-like changes in the central nervous system of an animal. This lesion should be shown only after the disease has advanced to the advanced stage and can not be detected early before the onset of clinical symptoms. In this paper, we report the high sensitivity of PrP ~ (SC) detected in the crude extracts of brain and spleen of mice infected with sheep itch