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目的对轻度肝功能异常进行开胸手术的患者，研究使用右美托咪定复合丙泊酚、瑞芬太尼进行麻醉的效果及适宜剂量。方法选取150例我院2012年4月~2014年4月收治的轻度肝功能异常患者，所有患者均需要行开胸术。将以上患者随机分为观察组A、观察组B、对照组各50例。观察组A、观察组B患者在麻醉诱导前15min静脉滴注右美托咪定负荷剂量0.8μg/kg，并分别在麻醉诱导行气管插管后开始静脉泵注右美托咪定0.2μg/(kg·h)、0.5μg/(kg·h)维持直到手术结束前0.5h；对照组患者给予等量的生理盐水静脉注射。结果观察组B患者的HR情况和不良反应发生率与观察组A患者相比，明显较好，P<0.05；观察组A患者的HR情况和不良反应发生率与对照组患者，明显较好，P<0.05。结论可见丙泊酚-瑞芬太尼复合0.5μg/(kg·h)右美托咪定是最佳维持剂量。“,”Objective For patients with mild liver function abnormalities were thoracotomy,Studies using dexmedetomidine given propofol,Remifentanil anesthesia ef icacy and appropriate dose.Methods Select the 150 cases in our hospital during 2012.4-2014.4 patients with mild hepatic dysfunction,al the patients must need a thoracotomy.The more patients were randomly divided into two groups A, observation group B,control group of 50 cases.Observation group A,group B patients was observed before induction of anesthesia 15min dexmedetomidine infusion given a loading dose of 0.8μg/kg,And respectively Intravenous infusion of dexmedetomidine given 0.2μgokg-1oh-after induction of anesthesia endotracheal intubation,0.5μgokg-1oh until half an hour before the end of surgery;In the control group were treated with normal saline intravenously.Results HR situation observed in patients in group B and the incidence of adverse reactions Compared with the observation group A patients,significantly bet er, <0.05.Conclusion Propofol-remifentanil 0.5μgokg-1oh-1 dexmedetomidine is the best maintenance dose given,worthy of clinical application.