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目的··：观察胍丁胺抗大鼠身体依赖作用与阿片受体间的关系。方法··：本文实验采用大鼠身体依赖实验和放射配体结合实验两种方法进行。结果··：胍丁胺虽然能剂量依赖性地抑制纳洛酮催促所引起的吗啡依赖大鼠戒断反应，但对３Ｈ－纳洛酮与大鼠前脑阿片受体结合反应无抑制作用（无直接作用），亦不能影响当身体依赖发生时阿片受体对配体的亲和力下降和受体数量下调等代偿性适应变化（无间接作用）。结论··：虽然胍丁胺能抑制阿片类药物身体依赖，但对阿片受体既无直接也无间接作用。
OBJECTIVE · To observe the relationship between agmatine’s antidepressant effect and opioid receptors in rats. Methods ··: This experiment using rat body-dependent experiments and radioligand binding experiments two methods. Results: Although agmatine inhibited the withdrawal of morphine-dependent rats induced by naloxone in a dose-dependent manner, there was no inhibitory effect of 3H-naloxone on the opioid receptor binding in rat forebrain No immediate effect), nor does it affect compensatory adaptations (indirect effects) such as decreased affinity of the opioid receptors to the ligand and decreased number of receptors when the body dependence occurs. CONCLUSIONS: Although agmatine inhibits opiate dependence on the body, it has neither direct nor indirect effects on opioid receptors.