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5. First Synthesis of 2α-Thiol Ether Analog of Docetaxel

First Synthesis of 2α-Thiol Ether Analog of Docetaxel

来源 :中国化学快报 | 被引量 : 0次 | 上传用户：xiaosheng2099

【摘 要】

：

A 2α-phenylthio ether analog 1c of docetaxel was synthesized for the first time from 10-deacetylbaccatin Ⅲ 3 via double inversion of C-2 configuration. This c

【作 者】

：

Wei Shuo FANG Ying LIU Qi Chen 

【机 构】

：

Institute of Materia Medica

【出 处】

：

中国化学快报

【发表日期】

：

2004年期

【关键词】

：

Paclitaxel docetaxel thiol ether 

【基金项目】

：

Financial support from Funding to Outstanding Doctor Thesis Authors of Chinese Universities

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论文部分内容阅读

A 2α-phenylthio ether analog 1c of docetaxel was synthesized for the first time from 10-deacetylbaccatin Ⅲ 3 via double inversion of C-2 configuration. This compound showed very weak cytotoxicity toward several tumor cell lines.

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