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1836年 Von Ludwig 曾叙述5例颈部结缔组织坏疽性硬结的患者。此病虽非常见,但有临床重要性,并发的呼吸梗阻对临床儿科医生是一个值得迫切提出的问题。病例材料:作者诊治的4例,全部为男患,年龄为19个月～10岁。均以舌和咽下间隙急性块状肿胀起病,呈典型的舌突出和公牛颈外貌。3例原有严重宿主防御功能缺乏,并与机合性细菌感染有关(绿脓杆菌、白色念珠菌),此3例死于呼吸道并发症(肺炎、上气道梗阻)。
Von Ludwig, 1836, described five patients with gangrene of neck connective tissue. Although the disease is very common, but the clinical importance of concurrent respiratory obstruction is an urgent issue for clinical pediatricians. Case material: The author diagnosis and treatment of 4 cases, all male patients, aged 19 months to 10 years old. Both tongue and swallow an acute swollen block onset, showing typical tongue and bull neck appearance. Three cases of the original serious lack of host defense, and associated with maternal bacterial infections (Pseudomonas aeruginosa, Candida albicans), the three cases of respiratory complications (pneumonia, upper airway obstruction).