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为从蛋白水平和基因表达水平探讨ＮＯ在高碳酸血症引起肺血管收缩而导致肺动脉高压中的作用环节 ,本实验采用体外培养大鼠肺微血管内皮细胞 (ＰＭＥＣｓ) ,分别研究单纯改变 ｐＨ与单纯改变ＣＯ2 浓度对其一氧化氮合酶 (ＮＯＳ)活性及其ｍＲ ＮＡ表达的影响 ,并比较ＰＭＥＣｓ
In order to explore the role of nitric oxide (NO) in the pulmonary hypertension caused by hypercapnia induced by hypercapnia in cultured rat pulmonary microvascular endothelial cells (PMECs) in vitro and in vivo, The effects of CO2 concentration on the activity of nitric oxide synthase (NOS) and the expression of mR NA were compared. PMECs