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测定了６８例正常人和５９例慢性肺心病患者血浆血管因子Ⅷ相关抗原（ⅧＡ：Ａｇ）浓度，并将慢性肺心病患者随机分为常规治疗组和抗凝治疗组。结果显示，慢性肺心病急性加重期血浆ⅧＡ：Ａｇ浓度极显著高于正常人（Ｐ＜０．００１）。经常规治疗后血浆ⅧＡ：Ａｇ浓度明显下降（Ｐ＜０．０５），抗凝治疗后血浆ⅧＡ：Ａｇ浓度下降更为显著（Ｐ＜０．０ｌ），而且抗凝治疗后血浆ⅧＡ：Ａｇ浓度下降程度极显著大于常规治疗（Ｐ＜０．００ｌ）。表明血浆ⅧＡ：Ａｇ浓度是反映慢性肺心病患者病情变化和高凝状态有重要价值的临床指标，抗凝治疗可使慢性肺心病急性加重期血浆ⅧＡ：Ａｇ浓度下降更为显著。
The plasma levels of angiotensin Ⅷ-associated antigen (ⅧA: Ag) were measured in 68 normal subjects and 59 patients with chronic cor pulmonale. Patients with chronic cor pulmonale were randomly divided into routine treatment group and anticoagulant treatment group. The results showed that the plasma concentration of ⅧA: Ag in acute exacerbation of chronic pulmonary heart disease was significantly higher than that in normal people (P <0.001). After conventional treatment, the plasma concentration of ⅧA: Ag decreased significantly (P <0.05), and the plasma concentration of ⅧA: Ag decreased more significantly after anticoagulation (P <0.01), and the plasma concentration of ⅧA: Ag The decline was significantly greater than the conventional treatment (P <0.00l). The results showed that plasma ⅧA: Ag concentration is a clinical indicator reflecting the change of the disease and hypercoagulable state in patients with chronic cor pulmonale. Anticoagulant therapy can make the plasma ⅧA: Ag concentration drop more significantly in the acute exacerbation of chronic pulmonary heart disease.