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目的:探讨延黄妇炎清片治疗慢性盆腔炎的作用机制。方法:采用苯酚胶浆法制成大鼠慢性盆腔炎模型。随机将50只SD大鼠分为5组,即假手术组、模型对照组、阳性对照组(金鸡片)、延黄妇炎清片小剂量组、延黄妇炎清片大剂量组。连续灌胃服药1月后,检测大鼠血清中超氧化物歧化酶(SOD)、丙二醛(MDA)的含量。结果:与模型组比较,假手术组、延黄妇炎清片大、小剂量组及金鸡片组大鼠血清SOD水平明显增高,MDA含量明显降低,差异均有显著性或非常显著性意义(P<0.01,P<0.05)。结论:延黄妇炎清片通过影响SOD、MDA的含量而达到对慢性盆腔炎的治疗作用。
Objective: To investigate the mechanism of Yanhuang Fuyan Qingpian in treating chronic pelvic inflammatory disease. Methods: Chronic pelvic inflammatory disease rats were made by phenol glue method. Fifty SD rats were randomly divided into five groups: sham operation group, model control group, positive control group (Jinji Tablets), small dose of Yanhuang Fuyan Tablet and large dose of Yanhuang Fuyan Tablet. After continuous administration for one month, the contents of superoxide dismutase (SOD) and malondialdehyde (MDA) in serum of rats were measured. Results: Compared with the model group, the levels of SOD in the sham-operation group, the Yan-Huang Fu-Yan-Qing Tablets large and small dose group and the Jinji-Tablet group were significantly increased, while the MDA contents were significantly decreased, with significant or very significant differences P <0.01, P <0.05). Conclusion: Yanhuang Fu Yan Qingpian through the impact of SOD, MDA content and achieve the therapeutic effect of chronic pelvic inflammatory disease.