特发性膜性肾病(IMN)是导致成人肾病综合征的常见原因之一。其自然病程差异悬殊,部分患者未经治疗可自发缓解,还有一些患者则会持续进展,使得临床肾脏科医师对治疗抉择陷于两难境地。目前诸多研究表明,激素及免疫抑制剂治疗是有效的,但过早使用这些药物也可能使患者暴露于不必要的不良反应中。近年来,基于IMN的治疗研究成为热点,该文就IMN的治疗进展予以综述。 Idiopathic membranous nephropathy (IMN) is one of the common causes of adult nephrotic syndrome. Their natural course disparity, some patients spontaneously untreated without treatment, and some patients will continue to progress, making clinical nephrologists dilemma in the treatment of choice. Many studies show that hormones and immunosuppressive agents are effective, but premature use of these drugs may also expose patients to unnecessary adverse reactions. In recent years, IMN-based therapeutic research has become a hot spot, this article reviews the progress of IMN treatment.