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[目的]观察葱神清脂软胶囊对大鼠非酒精性脂肪肝(NAFLD)的保护作用,并初步探讨其相关机制。[方法]SD大鼠40只,随机分为正常组、模型组、葱神清脂软胶囊组和易善复组,每组10只。实验4周后观察各组大鼠血浆丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、肝组织中丙二醛(MDA)、过氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、一氧化氮(NO)、一氧化氮合酶(NOS)水平,以及病理组织学的特点。[结果]2个治疗组大鼠血浆ALT、AST水平,肝组织SOD、MDA、GSH-Px、NO和NOS水平与模型组比较,差异均有统计学意义(P<0.01,<0.05),组织学观察表明2治疗组均能明显减轻肝组织脂肪变性。[结论]葱神清脂软胶囊对大鼠NAFLD具有很好的保护作用,其机制可能与对抗脂质过氧化反应,减少自由基的损伤有关。
[Objective] To observe the protective effect of Onion Shen Qingzhi Soft Capsule on rat non-alcoholic fatty liver (NAFLD), and to explore its related mechanism. [Methods] A total of 40 SD rats were randomly divided into normal group, model group, Onion Shenqingzhi soft capsule group and Yishanfu group, with 10 rats in each group. After 4 weeks of experiment, plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione in liver tissue were observed in each group. Glyoperoxidase (GSH-Px), nitric oxide (NO), nitric oxide synthase (NOS) levels, and histopathological features. [Results] The plasma levels of ALT and AST in the two treatment groups and the levels of SOD, MDA, GSH-Px, NO and NOS in liver tissue were significantly different from those in the model group (P<0.01, <0.05). Studies have shown that both treatment groups can significantly reduce hepatic steatosis. [Conclusion] Onion Shen Qingzhi Soft Capsule has a good protective effect on rat NAFLD. The mechanism may be related to the anti-lipid peroxidation reaction and the reduction of free radical damage.