【摘 要】
：
Four new triterpene saponins, mandshunosides F-I (1-4), together with five known compounds (5-9), were isolated from the roots and rhizomes of Clematis mandshurica.Their structures were elucidated on the basis of spectroscopic evidences and hydrolysis pro
【机 构】
：
College of Pharmacy and Biological Engineering, Chengdu University, Chengdu 610106, China
论文部分内容阅读
Four new triterpene saponins, mandshunosides F-I (1-4), together with five known compounds (5-9), were isolated from the roots and rhizomes of Clematis mandshurica.Their structures were elucidated on the basis of spectroscopic evidences and hydrolysis products.Bisdesmosidic saponin (3-9) showed modest suppression of NO production with the inhibition ratios in the range of 51.3％-64.6％ at 50 μmol·L-1, whereas monodesmosidic saponins with a free carboxyl group at C-28 (1 and 2) showed potent inhibitory activities with IC50 values being 12.7 and 8.3 μmol·L-1, respectively.
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