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冠状动脉粥样硬化的发生与低密度脂蛋白及炎症反应、内皮功能减退等有关。近年来多项临床试验证实早期强化应用他汀类药物可以通过降低低密度脂蛋白、抗炎、改善内皮功能等途径改善急性冠脉综合征患者的预后。其中他汀类药物发挥的抗炎症反应、改善内皮功能等多效性作用日益受到重视。而应用血管内超声的研究发现强化他汀类治疗能够显著遏制甚至消退冠状动脉粥样斑块。
Coronary atherosclerosis occurs with low density lipoprotein and inflammatory response, endothelial dysfunction and so on. In recent years, a number of clinical trials confirmed that early intensive use of statins can improve the prognosis of patients with acute coronary syndromes by reducing the low-density lipoprotein, anti-inflammatory, improve endothelial function and other means. Among them, the statin drugs play an increasingly important role in anti-inflammatory response and improving endothelial function. The application of intravascular ultrasound study found that intensive statin therapy can significantly curb or even eliminate coronary atherosclerotic plaques.