【摘 要】
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Natural products and their derivatives have long been used as medicinal agents,and they still make up a significant fraction of clinically approved drugs.Natura
【机 构】
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Beijing National Laboratory for Molecular Sciences,State Key Laboratory of Natural and Biomimetic Dr
论文部分内容阅读
Natural products and their derivatives have long been used as medicinal agents,and they still make up a significant fraction of clinically approved drugs.Natural product synthesis provides a rich and unparalleled opportunity to develop new synthetic transformations,conceive novel and general strategies to access com-plex structures,and study the mechanism of action of bioactive targets.The combination of the tools and principles of chemistry,together with the tools of modern biology,allows us to create complex synthetic and natural molecules,comprising processes with novel biological,chemical and physical properties.This account will illustrate the opportunities that lie at this interface between synthetic organic chemistry and chemical biology by describing a series of exam-ples that we are actively working on in our laboratory at Peking University.We take the inspiration from mother nature to develop new synthetic strategies to achieve the efficient synthesis of complex natural products.In addition,we also conduct chemical biology studies for these bioactive natural products to eluci-date their cellular targets and mode of action.Moreover,we further use bioac-tive natural products to explore new biology and develop novel drug candidates for human diseases,such as cancers and infectious diseases.
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