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对 30 2例胃癌术前检测CA5 0、CA199、CA12 5、CA72 4、CEA、β2 -MG、SA、Fer等 8种肿瘤标志物 ,并按年龄、胃癌病期及病理分类分组分析。结果 :(1) 30 2例胃癌血清中 8种肿瘤标志物总的阳性率依次为 β2 -MG6 5 .9%、CA19932 .1%、CA72 42 9.5 %、SA2 4.5 %、CA12 5 16 .9%、CEA13 .2 %、CA5 0 11.6 %、Fer(- )。 (2 ) 8种肿瘤标志物阳性率与年龄大小均无关。 (3) β2 -MG、CA72 4、CA12 5、CA199、SA、CEA、在Ⅲ、Ⅳ期病例中均较敏感 ,且随病期增加 ,阳性率增高。 (4 )CA199和CA72 4对腺癌、β2 -MG和SA对低分化腺癌、β2 -MG和CA72 4对粘液癌、混合型癌阳性率较高。提示血清测β2 -MG、CA199、CA72 4、SA、CA12 5对胃癌的辅助诊断有一定应用价值
The tumor markers of CA2O, CA199, CA12 5, CA72 4, CEA, β 2 -MG, SA and Fer were detected preoperatively in 302 patients with gastric cancer, and grouped according to their age, gastric cancer stage and pathological classification. Results: (1) The total positive rate of 8 tumor markers in 326 cases of gastric cancer were β2 -MG6 5.9%, CA19932.1%, CA72 429.5 %, SA2 4.5 %, CA12 5 16 .9% , CEA 13.2%, CA5 0 11.6%, Fer(-). (2) The positive rate of 8 tumor markers was not related to age. (3) β2-MG, CA72 4, CA12 5, CA199, SA, and CEA were all more sensitive in cases of stage III and IV, and the positive rate increased with the increase of disease stage. (4) The positive rates of CA199 and CA72 4 on adenocarcinoma, β2-MG and SA on poorly differentiated adenocarcinoma, β2-MG and CA72 4 on mucinous carcinoma and mixed carcinoma were higher. It is suggested that serum β2 -MG, CA199, CA72 4, SA, CA12 5 have certain application value in the diagnosis of gastric cancer