论文部分内容阅读
目的观察秋茄(kandelia candel)乙醇提取物(QQ)对胰岛素抵抗大鼠胰岛素敏感性和糖耐量的影响,探讨秋茄对2型糖尿病的防治作用。方法动物连续高脂饲料喂养8周后,第5周起同时预防性给予QQ高、中、低剂量处理4周,在8周末采血测定空腹血糖(FBG)、血清胰岛素(FINS),测定糖耐量,并计算出胰岛素敏感指数(ISI)。结果 QQ高、中、低剂量组经预防性给药4周后明显改善胰岛素敏感指数,并改善糖耐量。结论 QQ可提高胰岛素敏感性,可防止和控制高脂高热量膳食诱导胰岛素抵抗的发生。
Objective To observe the effects of alcohol extract of kandelia candel (QQ) on insulin sensitivity and glucose tolerance in insulin resistant rats and to explore the preventive and therapeutic effects of candelilla on type 2 diabetes mellitus. Methods Animals were fed with high-fat diet for 8 weeks. At week 5, prophylactic high-dose, middle-dose and low-dose of QQ were administered for 4 weeks. Fasting blood glucose (FBG) and serum insulin (FINS) , And calculate the insulin sensitivity index (ISI). Results After 4 weeks of prophylactic administration, the high, middle and low doses of QQ group significantly improved the insulin sensitivity index and improved the glucose tolerance. Conclusion QQ can improve insulin sensitivity, prevent and control high-fat and high-calorie diet-induced insulin resistance.