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  5. Site-directed Chemical Modification of Recombinant Human aFGF Mutant with Polyethylene Glycol

Site-directed Chemical Modification of Recombinant Human aFGF Mutant with Polyethylene Glycol

来源 :中国化学快报（英文版） | 被引量 : 0次 | 上传用户：nie492195407
【摘 要】
：
A new product PEGylated rhaFGF was obtained by site-directed chemical modification.When compared with unmodified rhaFGF, PEGylated rhaFGF showed comparable bioa
【作 者】
：
Qing ZHENG Zhi Feng HUANG Xiao 
【机 构】
：
College of Pharmacy,Biopharmaceutical R&D Center of Jinan University
【出 处】
：
中国化学快报（英文版）
【发表日期】
：
2004年期
【关键词】
：
rhaFGF chemical modification PEGylated rhaFGF 
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A new product PEGylated rhaFGF was obtained by site-directed chemical modification.When compared with unmodified rhaFGF, PEGylated rhaFGF showed comparable bioactivity and superior stability at 37℃ in mouse serum and the stronger resistant potency to trypsin. This was accompanied by a substantial decreasing immunogenicity. Site-specific PEGylation of rhaFGF may increase its therapeutic potency in humans.
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