作者以急性服药试验研究了Ⅰ类抗心律失常新药Penticainide与较常用的几种药作对比。随机急性服药试验药为吡二丙胺300mg、氟卡胺200mg、美西律400mg、Penticainide7mg/kg和普罗帕酮450mg。服药后90分钟测定血浆浓度。以高级别室性心律失常完全消失、室性早搏次数减少90％以上为有效;这些效果必须在服药后30分钟开始、并维持2小时以上。 In this study, the author studied the acute anti-arrhythmic drug Penticainide in comparison with the more commonly used drugs. Random acute drug test drugs are pyridilamine 300mg, flecainide 200mg, mexiletine 400mg, Penticainide 7mg / kg and propafenone 450mg. 90 minutes after taking the plasma concentration measurement. Complete disappearance of high-grade ventricular arrhythmias, ventricular premature beats more than 90% reduction for the effective; these effects must be 30 minutes after taking the medication, and maintained for more than 2 hours.