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目的:探究布洛芬在治疗早产低体重儿动脉导管未闭(PDA)的临床疗效。方法:将该院近年来收治的152例早产低体重PDA患儿随机分为实验组和对照组,每组76例,实验组于生后24 h内口服布洛芬,首剂10 mg/kg,第2、3剂5 mg/kg。对照组给予安慰剂生理盐水1 ml/kg,第2、3剂0.5 ml/kg,每剂间隔24 h。观察两组患儿的治疗效果及不良反应。结果:第1疗程结束后实验组PDA关闭率为82.89%,高于对照组的42.11%,平均住院时间也短于对照组,两组比较差异有统计学意义(P<0.05)。实验组脑室周围白质软化,早期肺出血和支气管肺发育不良的发生率低于对照组(P<0.05),但两组脑室内出血和坏死性小肠结肠炎的发生率等差异无统计学意义(P>0.05)。结论:口服布洛芬治疗早产低体重儿PDA患者时可以明显提高动脉导管的关闭率,缩短住院时间,值得临床推广。
Objective: To investigate the clinical efficacy of ibuprofen in the treatment of preterm low birth weight patients with patent ductus arteriosus (PDA). Methods: A total of 152 preterm low birth weight children with PDA in our hospital in recent years were randomly divided into experimental group and control group with 76 cases in each group. The experimental group received ibuprofen at the first 24 hours after birth and the first dose of 10 mg / kg , 2,3 agents 5 mg / kg. The control group was given placebo saline 1 ml / kg, the second and third dose of 0.5 ml / kg, each dose interval of 24 h. The therapeutic effects and adverse reactions in both groups were observed. Results: After the first course of treatment, the PDA closure rate in the experimental group was 82.89%, higher than that in the control group (42.11%), and the average length of stay was also shorter than that in the control group. There was significant difference between the two groups (P <0.05). The incidence of periventricular leukomalacia, early pulmonary hemorrhage and bronchopulmonary dysplasia in the experimental group was lower than that in the control group (P <0.05), but there was no significant difference in the incidence of intraventricular hemorrhage and necrotizing enterocolitis between the two groups (P > 0.05). Conclusion: Oral ibuprofen treatment of preterm low birth weight infant patients with PDA can significantly improve the closure rate of the ductus arteriosus, shorten the hospital stay, worthy of clinical promotion.