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目的与方法：采用链霉菌抗生物素蛋白———过氧化物酶连结法（ＬＳＡＢ）免疫组化和图象定量分析技术检测５０例非小细胞型肺癌（其中伴有淋巴结转移者３２例，不伴转移者１８例）上皮生长因子受体（ＥＧＦＲ）的表达。结果：ＥＧＦＲ表达与肿瘤间质淋巴细胞浸润（ＴＩＬ）呈负相关（Ｐ＜０．０１），ＥＧＦＲ高表达时，ＴＩＬ浸润少，肺癌的转移率高（８３％）。ＥＧＦＲ的表达与肺癌的组织类型明显相关（Ｐ＜０．０５），但与肺癌的分化程度与转移无相关。结论：肿瘤细胞内ＥＧＦＲ的表达程度与体内肿瘤免疫机能密切相关，二者共同影响肺癌细胞的生长、分化和转移。
Objective and method: To detect 50 cases of non-small cell lung cancer (32 cases with lymph node metastasis) by streptavidin-peroxidase ligation (LSAB) immunohistochemistry and quantitative image analysis techniques. 18 cases without metastasis) Epithelial growth factor receptor (EGFR) expression. RESULTS: EGFR expression was negatively correlated with tumor interstitial lymphocyte infiltration (TIL) (P<0.01). When EGFR was highly expressed, TIL infiltration was less and the metastasis rate of lung cancer was higher (83%). The expression of EGFR was significantly associated with the histological type of lung cancer (P < 0.05), but it was not related to the degree of differentiation and metastasis of lung cancer. Conclusion: The expression of EGFR in tumor cells is closely related to tumor immune function in vivo. Both of them affect the growth, differentiation and metastasis of lung cancer cells.