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目的通过中药针剂三七总皂苷粉针、丹参粉针对急性脑梗死患者的临床疗效,验证中药针剂对急性脑梗死的神经保护作用机制。方法 80名急性脑梗死患者随机分成治疗组(三七总皂苷粉针0.4g/d),药物组(丹参粉针0.4g/d),于治疗前及治疗后2周测定血浆细胞间黏附分子-1、脂联素、高敏C-反应蛋白表达水平及神经功能缺损评分值。结果两组治疗后血脂联素含量均升高(P<0.05),细胞间黏附分子-1、高敏-C反应蛋白含量降低,治疗组明显优于对照组(P<0.05)。同时两组治疗后神经功能缺损评分值均有所下降,均以治疗组为优(P<0.05)。结论三七总皂苷粉针、丹参针对急性脑梗死有良好的脑保护作用。其作用机制在于通过降低局部脑组织细胞间黏附分子-1、高敏C-反应蛋白,升高脂联素的表达水平,从而减轻缺血性炎症反应,起到对缺血脑组织的神经保护作用。
Objective To investigate the neuroprotective mechanism of traditional Chinese medicine injection on acute cerebral infarction (ACI) through the traditional Chinese medicine injection Panax notoginseng saponin powder and Danshen powder in patients with acute cerebral infarction. Methods Eighty patients with acute cerebral infarction were randomly divided into treatment group (Panax notoginseng saponin 0.4g / d) and drug group (Salvia miltiorrhiza powder 0.4g / d). Before and after treatment, plasma intercellular adhesion molecule -1, adiponectin, high-sensitivity C-reactive protein expression and neurological deficit scores. Results The levels of plasma adiponectin increased (P <0.05) and the contents of intercellular adhesion molecule-1 and high-sensitive C-reactive protein in both groups decreased after treatment. The treatment group was significantly better than the control group (P <0.05). At the same time, the scores of neurological deficits decreased after treatment in both groups, both of which were superior to the treatment group (P <0.05). Conclusion Panax notoginseng powder and Salvia miltiorrhiza have a good brain protective effect on acute cerebral infarction. Its mechanism is to reduce ischemic inflammation by decreasing the expression of ICAM-1, Hypersensitive C-reactive protein and local adiponectin in brain tissue, thus playing a neuroprotective role in ischemic brain tissue .